Gao Wen-qian, Ma Jin-ling, Han Chun-guang, Wang Qiong, Zhu Ping, Yang Ting-shu
Department 1 of Geriatric Cardiology, General Hospital of Chinese PLA, Beijing 100853, China.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2010 May;26(2):207-9.
To explore the correlation of lymphocyte G protein-coupled receptor kinases 2 (GRK2) expression of the very elderly with chronic heart failure (HF) and heart ejection fraction (EF).
16 elderly patients with chronic heart failure were divided into 2 groups as following: EF < 45% (n=7), EF > or = 45% (n=9); and health elderly as control (n=8). Lymphocytes were obtained from blood, reverse transcription polymerase chain reaction were used to measure GRK2 mRNA levels.
Lymphocyte GRK2 mRNA levels of EF < 45% group were higher than that of EF > 45% group, which were greater than that of control.
Elevation of lymphocyte GRK2 levels in HF is associated with heart EF, lymphocytes may provide a surrogate for monitoring cardiac GRK2 in human HF.
探讨高龄老年人淋巴细胞G蛋白偶联受体激酶2（GRK2）表达与慢性心力衰竭（HF）及心脏射血分数（EF）的相关性。
将16例老年慢性心力衰竭患者按如下方法分为2组：EF<45%（n=7），EF≥45%（n=9）；并选取健康老年人作为对照组（n=8）。从血液中获取淋巴细胞，采用逆转录聚合酶链反应测量GRK2 mRNA水平。
EF<45%组淋巴细胞GRK2 mRNA水平高于EF≥45%组，且二者均高于对照组。
HF患者淋巴细胞GRK2水平升高与心脏EF相关，淋巴细胞可能为监测人类HF时心脏GRK2提供替代指标。
