[Effect of metoprolol on the expression of GRK2 in lymphocyte of advanced elderly patients with chronic heart failure].
作者信息
Gao Wen-qian, Han Chun-guang, Zhao Yue-xiang, Wang Qiong, Zhu Ping, Yang Ting-shu, Liu Yong-xue
机构信息
Department of Geriatric Cardiology, General Hospital of Chinese PLA, Beijing 100853, China.
出版信息
Nan Fang Yi Ke Da Xue Xue Bao. 2010 May;30(5):1132-3.
OBJECTIVE
To investigate the effect of metoprolol on the expression of G protein-coupled receptor kinases 2 (GRK2) in lymphocyte of advanced elderly patients with chronic heart failure.
METHODS
32 elderly patients with chronic heart failure were divided into control group and metoprolol group, 16 each. Conventional therapy was used in the control group, conventional therapy plua metoprolol was used in metoprolol group. The treatment courses were 8 weeks in both groups.
RESULTS
Left ventricular end-diastolic diameter and left ventricular ejection fraction were not different between the two groups. Lymphocyte GRK2 mRNA level in metoprolol group was lower than that in control group.
CONCLUSION
Metoprolol can inhibit the expression of GRK2 in lymphocyte of advanced elderly patients with chronic heart failure.
Zotero 插件