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[门静脉高压症选择性和非选择性分流术后的门静脉灌注]

[Portal perfusion following selective and non-selective diversions in portal hypertension].

作者信息

Mercado M A, Paquet K J, Klingele H, Klingele R

机构信息

Departamento de Cirugía, Hospital Heinz Kalk, Bad Kissingen, R.F.A.

出版信息

Rev Gastroenterol Mex. 1991 Jan-Mar;56(1):3-6.

PMID:2068508
Abstract

Derivative procedures to treat portal hypertension deprive the liver of the portal flow. Selective procedures maintain portal perfusion to the liver, but, nevertheless, have a slow tendency to lost it; low diameter portosystemic shunts partially maintain also portal flow. A study to compare postoperative portal blood flow was designed. In twenty three patients, twelve of them with a distal spleno renal shunt (DSRS) and eleven with a low diameter mesocaval interposition shunt (12 mm. Ring Reinformaced GORE-TEX) (LDMCI) a portal blood flow determination using computerized liver perfusion scintigraphy was performed in the postoperative period. In the DSRS group, no case of encephalopathy or rebleeding was recorded. All shunts were patent. Preoperative liver perfusion scintigraphy (LPS) showed a portal perfusion index (PPI) of 38.26% (range 25.2 to 62%) and in the postoperative period a PPI of 13.7 (range 0.8 to 31.7%). In the LDMCI, one case of encephalopathy (9%) and one case of rebleeding (9%) was recorded. LPS showed a preoperative PPI of 28.13% (range 12.4 to 55.7%) and in the postoperative period a PPI of 10.57% (range 0.8 to 20.4%). In the postoperative period, either with a selective or no selective shunt, a reduction in portal blood flow to the liver is to be expected, more apparent in patients with a total shunt. LDMCI control effectively the recurrence of bleeding esophageal varices, maintaining portal perfusion, too. Thus, LDMCI constitutes and excellent alternative for patients in whom a selective shunt is not possible to perform or indicated, particularly in those with portal hypertension secondary to alcoholic liver cirrhosis.

摘要

治疗门静脉高压的衍生手术会使肝脏失去门静脉血流。选择性手术可维持肝脏的门静脉灌注,但仍有缓慢失去灌注的趋势;小口径门体分流术也能部分维持门静脉血流。我们设计了一项研究来比较术后门静脉血流情况。在23例患者中,12例行远端脾肾分流术(DSRS),11例行小口径肠系膜上腔静脉间置分流术(12mm环形加强型GORE-TEX)(LDMCI),术后采用计算机化肝脏灌注闪烁显像术测定门静脉血流。在DSRS组,未记录到脑病或再出血病例。所有分流均通畅。术前肝脏灌注闪烁显像(LPS)显示门静脉灌注指数(PPI)为38.26%(范围25.2%至62%),术后PPI为13.7%(范围0.8%至31.7%)。在LDMCI组,记录到1例脑病(9%)和1例再出血(9%)。LPS显示术前PPI为28.13%(范围12.4%至55.7%),术后PPI为10.57%(范围0.8%至20.4%)。术后,无论是选择性还是非选择性分流,预计肝脏门静脉血流都会减少,在全分流患者中更为明显。LDMCI能有效控制食管静脉曲张出血的复发,同时维持门静脉灌注。因此,对于无法进行或不适合进行选择性分流的患者,尤其是酒精性肝硬化继发门静脉高压的患者,LDMCI是一种极佳的选择。

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1
[Portal perfusion following selective and non-selective diversions in portal hypertension].[门静脉高压症选择性和非选择性分流术后的门静脉灌注]
Rev Gastroenterol Mex. 1991 Jan-Mar;56(1):3-6.
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