Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Ave., Newark, NJ 07102, USA.
Clin Neurophysiol. 2011 Feb;122(2):320-38. doi: 10.1016/j.clinph.2010.05.035. Epub 2010 Aug 3.
To investigate the maturation of long-latency auditory evoked potentials (LLAEP) from 6 to 48 months in infants with a family history of language impairment (FH+) and control infants (FH-).
LLAEPs of seventeen FH+ infants were compared to 28 FH- infants at 6, 9, 12, 16, 24, 36 and 48 months. Participants received a passive oddball paradigm using fast- and slow-rate non-linguistic auditory stimuli and at 36 and 48 months completed a battery of standardized language and cognitive tests.
Overall, the morphology of LLAEP responses differed for fast- versus slow-rate stimuli. Significant age-related changes in latency and amplitude were observed. Group differences, favoring FH- infants, in the rate of maturation of LLAEPs were found. Responses to fast-rate stimuli predicted language abilities at 36 and 48 months of age.
The development of LLAEP in FH+ children is modulated by differences in the rate of maturation as well as variations in temporal processing abilities.
These findings provide evidence for the role of non-linguistic auditory processes in early language development and illustrate the utility of using a perceptual-processing skills model to further our understanding of the precursors of language development and impairment.
研究有语言障碍家族史（FH+）和无家族史（FH-）的婴儿从 6 至 48 个月时长潜伏期听觉诱发电位（LLAEP）的成熟情况。
将 17 名 FH+婴儿的 LLAEP 与 28 名 FH-婴儿的 LLAEP 在 6、9、12、16、24、36 和 48 个月时进行比较。参与者接受了被动的oddball 范式，使用快速和慢速非语言听觉刺激，在 36 和 48 个月时完成了一系列标准化的语言和认知测试。
总体而言，快速率与慢速率刺激的 LLAEP 反应形态不同。观察到潜伏期和振幅随年龄的显著变化。发现 LLAEP 成熟率存在有利于 FH-婴儿的组间差异。快速率刺激的反应可以预测 36 和 48 个月时的语言能力。
FH+儿童的 LLAEP 发育受到成熟率差异以及时间处理能力变化的调节。
这些发现为非语言听觉过程在早期语言发展中的作用提供了证据，并说明了使用感知处理技能模型来进一步了解语言发展和障碍的前兆的实用性。
