Laboratorio de Bioquímica, División de Estudios de Posgrado e Investigación, Facultad de Odontología, Universidad Nacional Autónoma de México, Ciudad de México, México.
Int Immunopharmacol. 2010 Sep;10(9):1003-9. doi: 10.1016/j.intimp.2010.05.012. Epub 2010 Jun 4.
Dental focal infections are infections in the mouth that cause subsequent infection and symptoms in other parts of the body. Dental conditions such as periodontitis have been associated with coronary heart disease. In this study, we investigated the effect of flavonoids on activation of mitogen-activated protein kinase (MAPK) family members, protein kinase B (AKT), and IL-1 beta expression by rat heart embryonic (H9c2) cells upon stimulation with LTA. Pretreatment with four flavonoids, including quercetin, genistein, quercetagetin, and luteolin diminished LTA-induced ERK1/2, JNK, p38, and AKT phosphorylation and IL-1 beta gene expression. Our findings indicate that flavonoids interfere with LTA signal transduction.
口腔局部感染是口腔内的感染，可导致身体其他部位的继发感染和症状。牙周炎等口腔状况与冠心病有关。在这项研究中，我们研究了类脂 A 刺激大鼠心脏胚胎 (H9c2) 细胞后，黄酮类化合物对丝裂原活化蛋白激酶 (MAPK) 家族成员、蛋白激酶 B (AKT) 和白细胞介素-1β表达的激活的影响。四种黄酮类化合物（包括槲皮素、染料木黄酮、槲皮苷和木樨草素）预处理可减弱 LTA 诱导的 ERK1/2、JNK、p38 和 AKT 磷酸化以及白细胞介素-1β基因表达。我们的研究结果表明，黄酮类化合物干扰了 LTA 的信号转导。
