Jiang X H, Yu G D, Yin Q Z
Laboratory of Neurobiology, Suzhou Medical College.
Sheng Li Xue Bao. 1991 Apr;43(2):120-7.
This study was undertaken to evaluate the analgesic effect of paraventricular nucleus (PVN) stimulation with tail stimulation-vocalization test. The mechanism of this analgesia was analysed with nuclear lesion and microinjection technique. The main results were as follows: (1) Electrical stimulation of the PVN could significantly enhance the pain threshold and increase the content of AVP in brainstem measured by radioimmunoassay. (2) Solitary tract nucleus (STN) lesion could eliminate the analgesic effect induced by PVN stimulation. (3) Intranuclear microinjection of AVP-antagonist and AVP-antiserum into the STN could block the analgesic effect of PVN stimulation. (4) Intranuclear microinjection of AVP into the STN could mimick the analgesic effect similar to that of PVN stimulation. These results suggest that electrical stimulation of the PVN could produce an analgesic effect. This effect might be mediated by the activation of VP-ergic neurons in PVN and upon releasing VP from the descending fibers, the activities of neurons in the STN are influenced.
本研究旨在通过尾部刺激-发声试验评估室旁核（PVN）刺激的镇痛效果。采用核损毁和微量注射技术分析这种镇痛作用的机制。主要结果如下：（1）电刺激PVN可显著提高痛阈，并通过放射免疫测定法增加脑干中精氨酸加压素（AVP）的含量。（2）孤束核（STN）损毁可消除PVN刺激诱导的镇痛作用。（3）向STN内微量注射AVP拮抗剂和AVP抗血清可阻断PVN刺激的镇痛作用。（4）向STN内微量注射AVP可模拟与PVN刺激相似的镇痛作用。这些结果表明，电刺激PVN可产生镇痛作用。这种作用可能是通过激活PVN中的VP能神经元介导的，并且从下行纤维释放VP后，会影响STN中神经元的活动。
