Su X, Zhang W Y, Ho S Y
Department of Physiology, Hebei Medical College, Shijiazhuang.
Sheng Li Xue Bao. 1991 Apr;43(2):164-70.
Changes of mean arterial pressure (MAP), heart rate (HR), respiration and renal sympathetic nerve activity (RSNA) induced by close-arterial administration of adenosine to carotid body (CB) were observed in 33 anesthetized rabbits. The results were as follows: (1) In response to intracarotid injections of adenosine, MAP decreased in a dose-dependent manner, while the frequency of respiration increases with little change in depth. Following carotid sinus denervation, intracarotid injection of adenosine still resulted in a decrease of MAP but with no changes in respiration. (2) By adding adenosine to perfusate of the isolated carotid sinus, both MAP and HR decreased, but these effects could be abolished by inactivation of carotid body. (3) MAP decreased and RSNA enhanced during perfusing adenosine into carotid sinus. These effects could be abolished by the section of sinus nerve or inactivation of CB. From the results obtained, it is considered that adenosine is capable of activating CB, decreasing MAP and heart rate but with a concomitant increases in respiration and RSNA.
在33只麻醉兔中观察了向颈动脉体（CB）动脉内近距离注射腺苷引起的平均动脉压（MAP）、心率（HR）、呼吸和肾交感神经活动（RSNA）的变化。结果如下：（1）对颈动脉内注射腺苷的反应，MAP呈剂量依赖性下降，而呼吸频率增加，深度变化不大。切断颈动脉窦神经后，颈动脉内注射腺苷仍导致MAP下降，但呼吸无变化。（2）在离体颈动脉窦灌流液中加入腺苷，MAP和HR均下降，但这些效应可通过使颈动脉体失活而消除。（3）向颈动脉窦灌流腺苷时，MAP下降，RSNA增强。这些效应可通过切断窦神经或使CB失活而消除。从获得的结果来看，认为腺苷能够激活CB，降低MAP和心率，但同时增加呼吸和RSNA。
