Hashimoto K, Karasawa F, Satoh T
Department of Anesthesiology, National Defense Medical College, Tokorozawa.
Masui. 1997 Dec;46(12):1562-9.
The effects of epidural midazolam on heart rate (HR), mean arterial pressure (MAP) and the renal sympathetic nerve activity (RSNA) were examined. Under alpha-choloralose anesthesia, 31 male Japanese-white rabbits received epidural catheterization and surgical procedures for measurement of the renal sympathetic nerve activity. Epidural low (0.05%) and high (0.5%) concentrations of midazolam did not affect HR, but significantly decreased MAP and RSNA-spikes (the spike count of RSNA). Intravenous flumazenil significantly increased MAP and RSNA-spikes. These findings suggest that the decrease in RSNA-spikes induced by epidural midazolam is derived from the benzodiazepine receptor. Intramuscular midazolam (0.5%) did not affect HR, but decreased MAP and RSNA-spikes significantly. In the spinal cord dissected rabbits, epidural midazolam (0.5%) did not affect HR and MAP, but significantly attenuated RSNA-spikes. In conclusion, epidural midazolam attenuated RSNA through the benzodiazepine receptors of both the spinal and supraspinal nervous system.
研究了硬膜外给予咪达唑仑对心率（HR）、平均动脉压（MAP）和肾交感神经活动（RSNA）的影响。在α-氯醛糖麻醉下，31只雄性日本白兔接受硬膜外导管插入术及用于测量肾交感神经活动的外科手术。硬膜外给予低浓度（0.05%）和高浓度（0.5%）的咪达唑仑不影响HR，但显著降低MAP和RSNA峰（RSNA的峰计数）。静脉注射氟马西尼显著增加MAP和RSNA峰。这些发现提示硬膜外给予咪达唑仑引起的RSNA峰减少源自苯二氮䓬受体。肌肉注射咪达唑仑（0.5%）不影响HR，但显著降低MAP和RSNA峰。在脊髓切断的兔中，硬膜外给予咪达唑仑（0.5%）不影响HR和MAP，但显著减弱RSNA峰。总之，硬膜外给予咪达唑仑通过脊髓和脊髓上神经系统的苯二氮䓬受体减弱RSNA。
