Eisen A, Yufe R, Trop D, Campbell I
Neurology. 1978 Jun;28(6):598-602. doi: 10.1212/wnl.28.6.598.
Regional intravascular injections of d-tubocurarine (0.3 mg) were administered in the hands of 23 normal subjects and 19 patients with multiple sclerosis. The degree of neuromuscular block and rate of recovery were determined by measuring the amplitude of the first dorsal interosseus muscle action potential which was evoked periodically by trains of five stimuli (3 Hz each) to the ulnar nerve. In normal subjects, the first response to the train returned to its preinjection level after 20.0 +/- 8.5 minutes and the fifth response after 27.6 +/- 7.8 minutes. Multiple sclerosis patients showed a significantly delayed recovery of the first response (58 percent of patients) and of the fifth response (42 percent), suggesting a latent defect of neuromuscular transmission.
对23名正常受试者和19名多发性硬化症患者的手部进行了区域血管内注射d - 筒箭毒碱（0.3毫克）。通过测量由对尺神经的五次刺激（每次3赫兹）的序列周期性诱发的第一背侧骨间肌动作电位的幅度，来确定神经肌肉阻滞的程度和恢复速率。在正常受试者中，对刺激序列的首次反应在20.0 +/- 8.5分钟后恢复到注射前水平，第五次反应在27.6 +/- 7.8分钟后恢复。多发性硬化症患者的首次反应（58%的患者）和第五次反应（42%）的恢复明显延迟，提示神经肌肉传递存在潜在缺陷。
