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患有 ADHD 症状的成年人中并存的精神科问题和压力性生活事件——一项基于瑞典双胞胎的大型人群研究。

Coexisting psychiatric problems and stressful life events in adults with symptoms of ADHD--a large Swedish population-based study of twins.

机构信息

Karolinska Institutet, Stockholm, Sweden.

出版信息

J Atten Disord. 2012 Jan;16(1):13-22. doi: 10.1177/1087054710376909. Epub 2010 Aug 4.

Abstract

OBJECTIVE

To explore the associations of subtypes of adult ADHD with other psychiatric problems, stressful life events, and sex differences.

METHOD

Odds ratios were calculated using information from 17,899 participants from a population-based survey of adult twins born in Sweden between 1959 and 1985.

RESULTS

Symptoms of attention deficit hyperactivity disorder (ADHD) were associated with an increased risk for symptoms of (odds ratio [95% confidence interval]): generalized anxiety disorder (5.6 [4.3; 6.5]), major depression (2.8 [2.4; 3.2]), bipolar disorder (8.0 [5.1; 12.6]), obsessive-compulsive disorder (3.9 [3.1; 4.9]), and alcohol dependence (2.6 [2.2; 3.1]). Symptoms of ADHD were found to be associated with an increased risk for stressful life events (1.8 [1.3; 2.4]). No significant difference in comorbidity was observed between the two sexes.

CONCLUSION

Both women and men with ADHD are at increased risk for symptoms of other psychiatric disorders. They are also at increased risk for stressful life events.

摘要

目的

探讨成人注意缺陷多动障碍(ADHD)亚型与其他精神问题、生活应激事件及性别差异的相关性。

方法

采用来自瑞典 1959 年至 1985 年间出生的成人双胞胎的基于人群的调查数据,计算了 17899 名参与者的比值比。

结果

ADHD 症状与以下症状的风险增加相关(比值比[95%置信区间]):广泛性焦虑症(5.6[4.3;6.5])、重度抑郁症(2.8[2.4;3.2])、双相情感障碍(8.0[5.1;12.6])、强迫症(3.9[3.1;4.9])和酒精依赖(2.6[2.2;3.1])。ADHD 症状与生活应激事件风险增加相关(1.8[1.3;2.4])。两性之间的合并症无显著差异。

结论

ADHD 患者无论是女性还是男性,出现其他精神障碍症状的风险均增加。他们出现生活应激事件的风险也增加。

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