阿托西汀治疗伴有 ADHD 症状的重度自闭症儿童的疗效：一项开放标签研究。
Efficacy of atomoxetine in children with severe autistic disorders and symptoms of ADHD: an open-label study.
机构信息
Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50000, Thailand.
出版信息
J Atten Disord. 2011 Nov;15(8):684-9. doi: 10.1177/1087054710376907. Epub 2010 Aug 4.
OBJECTIVE
This study aims to examine the efficacy of atomoxetine in treating symptoms of attention deficit hyperactivity disorder (ADHD) in children with severe autistic disorder.
METHOD
Children with severe autistic disorder who had symptoms of ADHD were given atomoxetine for 10 weeks. The efficacy of atomoxetine was evaluated by using the Aberrant Behavior Checklist (ABC) to rate ADHD symptoms at baseline, week 6, and week 10. The Clinical Global Impression-Improvement (CGI-I) scale was used as secondary outcome to assess the overall improvement of the children's development at week 10.
RESULTS
A total of 12 children participated in this study. Although CGI-I scores showed improvement at week 10, the ABC hyperactivity subscale did not show a significant improvement of the ADHD symptoms at baseline (M = 33.89) compared to those at week 10 (M = 31.78, p = .62).
CONCLUSION
Atomoxetine did not benefit children with severe autistic disorder who have ADHD symptoms.
目的
本研究旨在考察阿托西汀治疗伴有严重自闭症的儿童注意缺陷多动障碍（ADHD）症状的疗效。
方法
对伴有 ADHD 症状的严重自闭症儿童给予阿托西汀治疗 10 周。在基线、第 6 周和第 10 周使用异常行为检查表（ABC）评定 ADHD 症状，评估阿托西汀的疗效。采用临床总体印象-改善量表（CGI-I）作为次要结局，评估儿童在第 10 周时的整体发育改善情况。
结果
共有 12 名儿童参与本研究。虽然 CGI-I 评分在第 10 周时显示改善，但与基线相比（M=33.89），ABC 多动分量表在第 10 周时并未显示 ADHD 症状有显著改善（M=31.78，p=.62）。
结论
阿托西汀对伴有 ADHD 症状的严重自闭症儿童无益。
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