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J Neuropsychiatry Clin Neurosci. 2010 Summer;22(3):329-37. doi: 10.1176/jnp.2010.22.3.329.
To evaluate the relationship between cognitive status and incident delirium, 291 geriatric patients on internal medicine wards were evaluated on admission with the Mini-Mental State Examination (MMSE) and Confusion Assessment Method-Spanish. Those with incident delirium were assessed using the Delirium Rating Scale-Revised-98 (DRS-R98). Delirium incidence was 11.7%, and 82 patients (28.2%) had cognitive deficits on MMSE. As cognitive impairment worsened, the risk for delirium increased linearly, and for each unit of MMSE worsening the DRS-R98 severity score worsened 0.4 points (F=5.39, df=1, p=0.027). Optimal MMSE cutoff score from receiver-operating characteristic curve analysis was 24.5. Even mild cognitive deficits increase delirium risk and severity.
为了评估认知状态与谵妄发生的关系，我们对内科病房的 291 名老年患者进行了入院评估，使用的评估工具包括简易精神状态检查（MMSE）和西班牙版意识模糊评估法（CAM-S）。对于发生谵妄的患者，我们使用修订版谵妄评定量表-98（DRS-R98）进行评估。谵妄的发生率为 11.7%，82 名患者（28.2%）在 MMSE 上存在认知缺陷。随着认知障碍的恶化，谵妄的风险呈线性增加，MMSE 每恶化一个单位，DRS-R98 严重程度评分恶化 0.4 分（F=5.39，df=1，p=0.027）。受试者工作特征曲线分析得出的最佳 MMSE 截断值为 24.5。即使是轻度认知缺陷也会增加谵妄的风险和严重程度。
