Murai Kenichi
Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.
Yakugaku Zasshi. 2010 Aug;130(8):1011-6. doi: 10.1248/yakushi.130.1011.
This review describes the first method to prepare imidazolines from aldehydes and 1,2-diamines by condensation and successive oxidation using NBS in one-pot operation. The reaction proceeds under mild conditions and can be applied to various aromatic and aliphatic aldehydes and 1,2-diamines. The utility of this method is also demonstrated in the total synthesis of spongotine A and the preparation of a newly designed organocatalyst, C3-symmetric trisimidazoline 7.
本综述描述了一种通过一锅法缩合以及使用NBS进行连续氧化，由醛和1,2 - 二胺制备咪唑啉的方法。该反应在温和条件下进行，可应用于各种芳香族和脂肪族醛以及1,2 - 二胺。该方法的实用性还在海绵骨针素A的全合成以及一种新设计的有机催化剂C3 - 对称三咪唑啉7的制备中得到了证明。
