Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka, 565-0871 Japan.
Org Lett. 2010 Mar 5;12(5):964-6. doi: 10.1021/ol902958m.
C(3)-symmetric chiral trisimidazoline was designed and synthesized as a new entry of organocatalyst with the concept of constructing C(3)-symmetric molecules with three C(2)-symmetric chiral components, and the application of this novel catalyst to asymmetric conjugate addition of beta-ketoesters to nitroolefins was described.
C(3)-对称手性三氮唑啉作为一种新型手性有机催化剂被设计和合成，其设计概念是利用三个 C(2)-对称手性组分构建 C(3)-对称分子，并将这种新型催化剂应用于β-酮酯与硝基烯烃的不对称共轭加成反应中。
