Fujisaki Fumiko, Shoji Kaori, Shimodouzono Mari, Kashige Nobuhiro, Miake Fumio, Sumoto Kunihiro
Faculty of Pharmaceutical Science, Fukuoka University, Nanakuma, Jonan-ku, Fukuoka, Japan.
Chem Pharm Bull (Tokyo). 2010 Aug;58(8):1123-6. doi: 10.1248/cpb.58.1123.
To find new antibacterial leads in the class of hydantoin derivatives, we carried out synthetic investigation and biological evaluation of the title hydantoin derivatives and related compounds. Among the hydantoin derivatives described in this article, compound 3o, in which a 2,6-dichlorophenyl ring was introduced at the N-3 position of the hydantoin nucleus, showed the highest levels of antibacterial activity against both Escherichia coli NBRC14237 (NIHJ) and Staphylococcus aureus ATCC6538P (gram-negative and gram-positive bacteria, respectively) strains.
为了在乙内酰脲衍生物类别中寻找新的抗菌先导物，我们对标题中的乙内酰脲衍生物及相关化合物进行了合成研究和生物学评价。在本文所述的乙内酰脲衍生物中，化合物3o（其中在乙内酰脲核的N-3位引入了一个2,6-二氯苯环）对大肠杆菌NBRC14237（NIHJ）和金黄色葡萄球菌ATCC6538P（分别为革兰氏阴性菌和革兰氏阳性菌）菌株均表现出最高水平的抗菌活性。
