Radiation Therapy Program, BC Cancer Agency, Vancouver Island Centre, Victoria, British Columbia, Canada.
Am J Clin Oncol. 2011 Aug;34(4):350-5. doi: 10.1097/COC.0b013e3181e841ec.
To evaluate tolerability and compliance to a walking exercise program and its effect on fatigue during and after radical external beam radiation therapy (EBRT) for prostate cancer.
A total of 50 subjects with prostate cancer undergoing EBRT over 6 to 8 weeks were prospectively accrued to an exercise intervention group, matched for age and clinical characteristics to 30 subjects in a historical control group who underwent EBRT with no specific exercise intervention. Starting 1 week before EBRT, exercise participants performed moderate-intensity walking targeting 60% to 70% age-predicted maximum heart rate, at least 20 min/d, 3 d/wk over 12 weeks. The Brief Fatigue Inventory was administered at baseline, mid-EBRT (week 3-4), end-EBRT (week 6-8), and 6 months post-EBRT.
Of 50, 42 (84%) of exercise participants completed the walking program. There were no cardiovascular complications, musculoskeletal injuries, or other adverse events. A total of 89% subjects reported "Good-Excellent" satisfaction during and up to 6 months post-EBRT. Fatigue in control subjects escalated from baseline to end-EBRT, remaining high at 6 months post-EBRT (P[r] = 0.03). In contrast, mean total fatigue scores in exercise subjects were stable from baseline up to 6 months post-EBRT (P = 0.52). Trends for higher fatigue interference with quality of life were observed in the control group as compared with the exercise group.
Moderate-intensity walking exercise during radical EBRT is safe and feasible. The high convenience and satisfaction ratings, in conjunction with the observed fatigue trends, indicate that this activity has the potential to attenuate fatigue and improve quality of life for patients with localized prostate cancer undergoing curative therapy.
评估步行运动方案的耐受性和依从性，及其对根治性体外放射治疗（EBRT）期间和之后前列腺癌疲劳的影响。
共前瞻性纳入 50 例接受 EBRT 治疗的前列腺癌患者，将他们分为运动干预组，这些患者在 6 至 8 周内接受 EBRT，年龄和临床特征与 30 例接受 EBRT 且无特定运动干预的历史对照组患者相匹配。从 EBRT 前 1 周开始，运动参与者进行中等强度的步行运动，目标是达到 60%至 70%的年龄预测最大心率，每次至少 20 分钟，每周 3 天，持续 12 周。在基线、EBRT 中期（第 3-4 周）、EBRT 结束时（第 6-8 周）和 EBRT 后 6 个月时使用简明疲劳量表进行评估。
在 50 例患者中，42 例（84%）完成了步行计划。没有发生心血管并发症、肌肉骨骼损伤或其他不良事件。共有 89%的患者报告在 EBRT 期间和 EBRT 后 6 个月内“良好-优秀”满意度。对照组的疲劳程度从基线升高到 EBRT 结束时，在 EBRT 后 6 个月仍较高（P[r] = 0.03）。相比之下，运动组患者的总疲劳评分从基线到 EBRT 后 6 个月保持稳定（P = 0.52）。与运动组相比，对照组患者的生活质量受疲劳干扰的趋势更高。
在根治性 EBRT 期间进行中等强度的步行运动是安全可行的。高便利性和满意度评分，加上观察到的疲劳趋势，表明这种活动有可能减轻疲劳，改善接受根治性治疗的局限性前列腺癌患者的生活质量。
