Ganter M, Bickhardt K, Stockhofe N, Kamphues J
Klinik für kleine Klauentiere und forensische Medizin der Tierärztlichen Hochschule Hannover.
Tierarztl Prax. 1991 Apr;19(2):141-6.
In a flock of sheep to which food with excess copper (= Cu) had been fed for some months 39 animals died of chronic copper toxicosis. In 5 sheep of this flock the plasma concentrations of the enzymes glutamate dehydrogenase (GLDH), sorbitol dehydrogenase (SDH), aspartate-amino-transferase (ASAT) and copper were measured several times over a period of 100 days. At day 23, 58 and 97 needle biopsies of the liver were taken. The biopsies were used for histological examination and Cu-analysis. After 100 days the sheep were slaughtered and chronic copper poisoning was diagnosed by raised Cu concentration and typical histological alterations in the liver. The activities of GLDH and SDH in the plasma of the 5 sheep were consistently above normal, ASAT activity and the plasma Cu level were raised only occasionally. The results of Cu determination in biopsy samples were of little predictive value compared with post mortem Cu analysis of the liver.
在一群连续数月被喂食了过量铜（=Cu）的绵羊中，有39只动物死于慢性铜中毒。在这群绵羊中的5只羊身上，在100天的时间里多次测量了血浆中谷氨酸脱氢酶（GLDH）、山梨醇脱氢酶（SDH）、天冬氨酸氨基转移酶（ASAT）的浓度以及铜的含量。在第23天、58天和97天对肝脏进行了针刺活检。活检样本用于组织学检查和铜分析。100天后，这些绵羊被屠宰，并通过肝脏中铜浓度升高和典型的组织学改变诊断为慢性铜中毒。与肝脏的死后铜分析相比，活检样本中的铜测定结果几乎没有预测价值。
