Otorhinolaryngology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan Italy.
Head Neck. 2011 May;33(5):673-8. doi: 10.1002/hed.21519. Epub 2010 Aug 4.
The purpose of the present study was to report the oncological and functional results of our experience in open organ preservation surgery of the larynx.
Between 1978 and 2006, 140 patients were treated with organ preservation surgery of the larynx. Feeding tube and tracheotomy duration, surgical infection, fistulae, and pneumonia were recorded.
Most patients were treated with supraglottic laryngectomies. Thirteen patients (9%) experienced a faringo-cutaneous fistula, 23 (16%) presented with a surgical site infection, and 6 (4%) developed pneumonia. Tracheotomy was maintained for a median period of 47 days in patients who did not receive postoperative radiotherapy (RT) and 140 days in patients who did. Eight (6%) total laryngectomies were performed because of oncological and functional reasons. Tube feeding continued for an average period of 34 days. Patients with squamous cell carcinoma (SCC) had 5-year disease-free survival (DFS) of 83.6%.
Open organ preservation surgery proved oncologically effective with good functional outcome and acceptable complications.
本研究旨在报告我们在开放性器官保留手术治疗喉癌方面的肿瘤学和功能学结果。
1978 年至 2006 年间，140 例患者接受了喉器官保留手术治疗。记录了置管和气管切开时间、手术感染、瘘管和肺炎。
大多数患者接受了喉声门上切除术。13 例（9%）发生咽皮瘘，23 例（16%）出现手术部位感染，6 例（4%）发生肺炎。未接受术后放疗（RT）的患者气管切开时间中位数为 47 天，接受 RT 的患者为 140 天。8 例（6%）因肿瘤学和功能原因行全喉切除术。管饲持续时间平均为 34 天。鳞状细胞癌（SCC）患者的 5 年无病生存率（DFS）为 83.6%。
开放性器官保留手术在肿瘤学上有效，具有良好的功能结果和可接受的并发症。
