Department of Otorhinolaryngology, Hospital Universitario Central de Asturias, Instituto Universitario de Oncología del Principado de Asturias, University of Oviedo, C/Celestino Villamil, 33006 Oviedo, Spain.
Eur Arch Otorhinolaryngol. 2012 Sep;269(9):2081-6. doi: 10.1007/s00405-012-2016-5. Epub 2012 Apr 7.
There are several therapeutic options for laryngeal cancer, including those that provide a functional preservation without worsening the oncological results, such as transoral laser microsurgery (TLM). The aim of this study was to analyze both oncological and functional results of TLM in supraglottic cancer. We studied 49 consecutive patients with a primary supraglottic carcinoma who underwent a TLM between the years 1999 and 2009. Nineteen patients were classified as stage I-II and 30 as stage III-IV disease. Forty-five patients underwent also neck dissection. Thirteen patients received postoperative radiotherapy. The minimum follow-up was 24 months. Three- and five-year disease-specific survival rate was 93.2 and 82.2 %, respectively. Of the patients, 36.7 % had some complication after surgery, aspiration being the most frequent (16.32 %). Of the 43 patients who were alive, 39 (91 %) without evidence of disease 3 years after diagnosis had a functional larynx. Our results suggest that TLM is a safe and effective treatment for supraglottic cancer, with a low morbidity rate and excellent functional results.
有几种治疗喉癌的选择，包括那些在不恶化肿瘤学结果的情况下提供功能保留的选择，如经口激光微创手术（TLM）。本研究的目的是分析 TLM 在声门上型癌症中的肿瘤学和功能结果。我们研究了 49 例连续接受 TLM 的原发性声门上型癌患者，这些患者于 1999 年至 2009 年间接受了治疗。19 例患者被分类为 I-II 期，30 例患者被分类为 III-IV 期疾病。45 例患者还接受了颈部清扫术。13 例患者接受了术后放疗。最小随访时间为 24 个月。3 年和 5 年疾病特异性生存率分别为 93.2%和 82.2%。术后，有 36.7%的患者出现了一些并发症，其中最常见的是吸入（16.32%）。在 43 例存活的患者中，有 39 例（91%）在诊断后 3 年内无疾病证据，具有功能性喉。我们的结果表明，TLM 是治疗声门上型癌症的一种安全有效的方法，发病率低，功能结果良好。
