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[生酮饮食的抗惊厥和神经保护作用]

[Anticonvulsant and neuroprotective effects of the ketogenic diet].

作者信息

Choragiewicz Tomasz, Zarnowska Iwona, Gasior Maciej, Zarnowski Tomasz

机构信息

Katedra i Klinika Okulistyki, Uniwersytet Medyczny, Lublin.

出版信息

Przegl Lek. 2010;67(3):205-12.

Abstract

Ketogenic diet has been used in treating epilepsy for more than 80 years. It is based on a drastic change of proportions in the consumption of carbohydrates, proteins and fats. In everyday diet we consume approximately 34 per cent of fats, 50 per cent of carbohydrates and 14 per cent of proteins. While ketogenic diet consists in 80-90 per cent of fats and in 10-20 per cents of carbohydrates and proteins together. Despite its indisputable effectiveness, the functioning of the ketogenic diet has not been explained. It seems that its functioning mechanism is unique and results from a number of chronic metabolic changes as well as the adaptation in the cenral nervous system that occurs during its long-term application. The most recent clinical and experimental data suggest that the ketogenic diet also has neuroprotective properties, which makes it a useful alternative therapeutic method in the modification of the natural history of the diseases related with neurodegeneration processes.

摘要

生酮饮食用于治疗癫痫已有80多年的历史。它基于碳水化合物、蛋白质和脂肪摄入比例的剧烈变化。在日常饮食中,我们大约摄入34%的脂肪、50%的碳水化合物和14%的蛋白质。而生酮饮食中脂肪占80 - 90%,碳水化合物和蛋白质总共占10 - 20%。尽管其有效性无可争议,但生酮饮食的作用机制尚未得到解释。其作用机制似乎很独特,是由一些慢性代谢变化以及长期应用过程中中枢神经系统发生的适应性变化导致的。最新的临床和实验数据表明,生酮饮食还具有神经保护特性,这使其成为改变与神经退行性变过程相关疾病自然病程的一种有用的替代治疗方法。

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