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过氧化物酶体增殖物激活受体α与生酮饮食

Peroxisome proliferator-activated receptor alpha and the ketogenic diet.

作者信息

Cullingford Tim

机构信息

National Heart and Lung Institute Division, Faculty of Medicine, Imperial College, London, United Kingdom.

出版信息

Epilepsia. 2008 Nov;49 Suppl 8:70-2. doi: 10.1111/j.1528-1167.2008.01840.x.

DOI:10.1111/j.1528-1167.2008.01840.x
PMID:19049593
Abstract

Peroxisome proliferator-activated receptor alpha (PPARalpha) is a drug/fatty acid-activated trans cription factor involved in the starvation response, and is thus relevant to the ketogenic diet (KD). This article summarizes research indicating the role of PPARalpha in central and peripheral nervous system function with particular reference to downstream targets relevant to anticonvulsant action.

摘要

过氧化物酶体增殖物激活受体α（PPARα）是一种药物/脂肪酸激活的转录因子，参与饥饿反应，因此与生酮饮食（KD）相关。本文总结了相关研究，这些研究表明PPARα在中枢和外周神经系统功能中的作用，特别提及了与抗惊厥作用相关的下游靶点。

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