Kekulé-Institut für Organische Chemie und Biochemie der Universität Bonn, Gerhard Domagk Strasse 1, 53121 Bonn, Germany.
J Am Chem Soc. 2010 Sep 1;132(34):11858-9. doi: 10.1021/ja105023y.
A catalytic enantio- and diastereoselective radical cyclization using a regiodivergent epoxide opening (REO) for radical generation is described. It is demonstrated for the first time that the diastereoselectivity of cyclizations of acyclic radicals can be controlled catalytically. Building blocks for important applications in stereoselective synthesis are readily accessed.
本文描述了一种使用区域发散的环氧化物开环（REO）生成自由基的催化对映选择性和非对映选择性自由基环化反应。首次证明了无环自由基环化的非对映选择性可以通过催化控制。立体选择性合成中重要应用的砌块可以很容易地获得。
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