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自膨式金属支架内镜下置入治疗食管癌

Self expandable metallic stent endoscopic insertion in esophageal cancer.

作者信息

Siddiqui Ali Akbar, Ansari Shoaib, Ghouri Muhammad Aamir, Memon Muhammad Sadik

机构信息

Department of Medicine, Section of Gastroenterology, Isra University Hospital, Hyderabad.

出版信息

J Coll Physicians Surg Pak. 2010 Aug;20(8):502-5.

Abstract

OBJECTIVE

To determine the safety of self expandable metallic stent (SEMS) placement under endoscopic guidance without fluoroscopy.

STUDY DESIGN

Quasi experimental study.

PLACE AND DURATION OF STUDY

Section of Gastroenterology and Hepatology, Departments of Medicine, Isra University Hospital and Liaquat University of Medical and Health Sciences (LUMHS), Hyderabad, from April 2006 to March 2009.

METHODOLOGY

In 80 patients with inoperable carcinoma of esophagus, SEMS made-up of nickel titanium alloy and mesh shaped with distal release system were placed without the use of fluoroscope under endoscopic guidance. Patients with proximal location of tumour in esophagus were excluded. They were followed at one week after deployment. All the complications were recorded. Dysphagia score was assessed before and after stent placement. Mean pre- and poststenting scores were compared using t-test.

RESULTS

Fluoroscopy was needed in only 2 patients. In 75 patients the stent was successfully placed with endoscope control only, without fluoroscope. Dysphagia score improved significantly from 4.26+/-1.07 before stenting to 1.02+/-0.57 later, (p<0.001). Minor complications like retrosternal pain occurred in 30 (37.5%) patients and major complications in 8 (10.0%) patients amongst which 4 (5.0%) developed upper gastrointestinal bleeding and 4 patients (5.0%) had aspiration.

CONCLUSION

Insertion of self expandable metallic stent in esophageal carcinoma without fluoroscope was safe and effective in relieving dysphagia at short term follow-up.

摘要

目的

确定在内镜引导下不使用荧光透视进行自膨式金属支架(SEMS)置入的安全性。

研究设计

准实验性研究。

研究地点及时间

2006年4月至2009年3月,伊斯雷尔大学医院和利亚卡特医学与健康科学大学(LUMHS)医学部胃肠病学和肝病科,海得拉巴。

方法

选取80例无法手术的食管癌患者,在内镜引导下不使用荧光透视仪置入由镍钛合金制成且带有远端释放系统的网状SEMS。排除肿瘤位于食管近端的患者。在支架置入后1周对患者进行随访。记录所有并发症。评估支架置入前后的吞咽困难评分。使用t检验比较置入支架前后的平均评分。

结果

仅2例患者需要荧光透视。75例患者仅在内镜控制下成功置入支架,未使用荧光透视。吞咽困难评分从置入支架前的4.26±1.07显著改善至之后的1.02±0.57,(p<0.001)。30例(37.5%)患者出现胸骨后疼痛等轻微并发症,8例(10.0%)患者出现严重并发症,其中4例(5.0%)发生上消化道出血,4例(5.0%)出现误吸。

结论

在食管癌患者中不使用荧光透视置入自膨式金属支架在短期随访中缓解吞咽困难是安全有效的。

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