Ipswich Hospital NHS Trust, Ipswich, IP4 5PD, UK.
Rheum Dis Clin North Am. 2010 Aug;36(3):447-61. doi: 10.1016/j.rdc.2010.04.002. Epub 2010 Jun 15.
The epidemiology of the antineutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV), comprising Wegener's granulomatosis, microscopic polyangiitis, and Churg-Strauss syndrome, poses considerable challenges to epidemiologists. These challenges include the difficulty of defining a case with a lack of clear distinction between the different disorders, case capture, and case ascertainment. The AAV are rare and therefore a large population is required to determine the incidence and prevalence, and this poses questions of feasibility. Despite these difficulties a considerable body of data on the epidemiology of the AAV has been built in the past 20 years with an interesting age, geographic, and ethnic tropism gradually being revealed. Most of the data come from White populations of European descent, and the overall annual incidence is estimated at approximately 10-20/million with a peak age of onset in those aged 65 to 74 years.
抗中性粒细胞胞浆抗体（ANCA）相关血管炎（AAV）的流行病学，包括韦格纳肉芽肿、显微镜下多血管炎和变应性肉芽肿性血管炎，给流行病学家带来了相当大的挑战。这些挑战包括缺乏不同疾病之间明确区分的情况下定义病例的困难、病例捕获和病例确定。AAV 较为罕见，因此需要大量人群来确定发病率和患病率，这就提出了可行性问题。尽管存在这些困难，但在过去 20 年中，已经积累了相当多的关于 AAV 流行病学的数据，逐渐揭示了其有趣的年龄、地理和种族倾向。这些数据大多来自欧洲血统的白人人群，估计总的年发病率约为每百万人 10-20 例，发病高峰年龄为 65 至 74 岁。
