Marco-Algarra J, Honrubia V
Hospital Clínico Universitario, Universitat de Valencia, Spain.
Acta Otolaryngol. 1991;111(2):162-8. doi: 10.3109/00016489109137369.
The ototoxic effect of an aminoglycoside, gentamicin, on the vestibular system was investigated in cats given daily doses of 40 mg/kg i.m. for 14 days. Periodically, measurements were made of the vestibulo-ocular reflex (VOR) and visual vestibulo-ocular reflex (ViVOR) responses induced by rotatory stimuli at various frequencies from 0.0125 Hz to 0.8 Hz. After the cessation of drug administration, a progressively declining response to VOR stimuli continued, manifested by gain (ratio of peak response to peak stimulus amplitude) and phase relationships. The ViVOR was affected only in the gain measurements. The changes in the response amplitude (gain) were greater for the VOR than for the ViVOR responses and also for the lower (0.0125 Hz) than for the higher frequencies (0.8 Hz). There was some indication that the responses improved about one month after treatment was terminated. All of these specific response changes in cats are comparable to the known effects of aminoglycides in humans, and the same theoretical interpretation of the data in the context of a model of vestibular function can be applied in both cases.
研究了氨基糖苷类药物庆大霉素对猫前庭系统的耳毒性作用，给猫每日肌肉注射40mg/kg，持续14天。定期测量在0.0125Hz至0.8Hz不同频率旋转刺激下诱发的前庭眼反射（VOR）和视觉前庭眼反射（ViVOR）反应。停药后，对VOR刺激的反应持续逐渐下降，表现为增益（峰值反应与峰值刺激幅度之比）和相位关系。ViVOR仅在增益测量中受到影响。VOR反应幅度（增益）的变化比ViVOR反应更大，且低频（0.0125Hz）时的变化比高频（0.8Hz）时更大。有迹象表明，治疗终止约一个月后反应有所改善。猫的所有这些特定反应变化与氨基糖苷类药物在人类中的已知作用相当，并且在两种情况下都可以在前庭功能模型的背景下对数据应用相同的理论解释。
