Black F O, Peterka R J, Elardo S M
Laryngoscope. 1987 May;97(5):582-6. doi: 10.1288/00005537-198705000-00008.
The effects of aminoglycoside-induced changes on the vestibular system were evaluated in three subjects who suffered significant damage over the course of treatment. Measurements of vestibulo-ocular reflex (VOR) function were made using sinusoidal and pseudorandom rotational stimuli between 0 to 5 days after initiation of drug therapy, during drug therapy, and up to 579 days following drug administration. All subjects tested at baseline evaluations had normal VOR function. During aminoglycoside therapy there was a precipitous drop in both the VOR time and gain constants. The decline in VOR function was larger at lower stimulus frequencies compared to high frequencies, resulting in a relative preservation of function in the high frequencies. Over a period of about a year, VOR high frequency gains recovered to within normal limits. However, the VOR time constants showed only a modest recovery and remained well below the normal range.
在三名治疗过程中遭受严重损害的受试者中评估了氨基糖苷类药物引起的变化对前庭系统的影响。在开始药物治疗后的0至5天、药物治疗期间以及给药后长达579天，使用正弦和伪随机旋转刺激对前庭眼反射（VOR）功能进行测量。所有在基线评估时接受测试的受试者VOR功能均正常。在氨基糖苷类药物治疗期间，VOR时间和增益常数均急剧下降。与高频相比，低频时VOR功能下降幅度更大，导致高频功能相对保留。在大约一年的时间里，VOR高频增益恢复到正常范围内。然而，VOR时间常数仅显示出适度恢复，仍远低于正常范围。
