Fischer A J
St. Jans-Gasthuis, Weert, The Netherlands.
Acta Otolaryngol Suppl. 1991;479:24-8. doi: 10.3109/00016489109121145.
The vasodilating properties of histamine were the basis for histamine treatment of episodic vertigo and other inner ear dysfunctions. The successes obtained led to the development of betahistine: an orally active histamine analogue; its general pharmacology resembles that of histamine. Animal pharmacology experiments proved that betahistine increases cerebral blood flow and probably also affects vestibular neurons. From clinical studies, it appears that betahistine is an effective agent for the symptomatic treatment of Meniere's syndrome. Efficacy has also been shown in the treatment of patients suffering from paroxysmal vertigo.
组胺的血管舒张特性是其用于治疗发作性眩晕和其他内耳功能障碍的基础。所取得的成功促使了倍他司汀的研发：一种口服活性组胺类似物；其一般药理学特性与组胺相似。动物药理学实验证明，倍他司汀可增加脑血流量，可能还会影响前庭神经元。从临床研究来看，倍他司汀似乎是治疗梅尼埃病综合征症状的有效药物。在治疗阵发性眩晕患者方面也已显示出疗效。
