Takeya M, Naito M, Eto K, Takahashi K
Second Department of Pathology, Kumamoto University Medical School, Japan.
Acta Pathol Jpn. 1991 Mar;41(3):212-6. doi: 10.1111/j.1440-1827.1991.tb01649.x.
In an autopsy case of a 35-year-old Japanese hemophiliac with acquired immune deficiency syndrome (AIDS), many multinucleated giant cells (MGCs) were observed throughout the central nervous system. Immunohistochemically, MGCs possessed surface and cytoplasmic macrophage antigens expressed in the late stage of differentiation indicating them to be macrophages in the terminal stage of differentiation. Fine nuclear extensions connecting one nucleus (or lobe) to another were often observed in the MGCs. This feature was interpreted as multilobulation and considered to be a morphological characteristic of MGCs in AIDS encephalopathy. Similarity between MGCs in AIDS encephalopathy and highly lobulated lymphocytes in adult T cell leukemia is discussed.
在一名患有获得性免疫缺陷综合征（艾滋病）的35岁日本血友病患者的尸检病例中，在整个中枢神经系统中观察到许多多核巨细胞（MGCs）。免疫组织化学显示，MGCs具有在分化后期表达的表面和细胞质巨噬细胞抗原，表明它们是分化末期的巨噬细胞。在MGCs中经常观察到连接一个细胞核（或叶）与另一个细胞核的精细核延伸。这一特征被解释为多叶状，并被认为是艾滋病脑病中MGCs的形态学特征。文中讨论了艾滋病脑病中的MGCs与成人T细胞白血病中高度分叶的淋巴细胞之间的相似性。
