Kim C, Cervós-Navarro J
Freie Universität Berlin, Institut für Neuropathologie, Federal Republic of Germany.
Acta Neurochir (Wien). 1991;109(1-2):63-5. doi: 10.1007/BF01405700.
A saccular cerebral aneurysm was incidentally found at the bifurcation of a fenestrated anterior cerebral artery of 35-week-old Sprague-Dawley rat. The animal had been fed a normal laboratory diet. The internal lamina extended for a short distance into the neck of the aneurysm and then suddenly disappeared. The medial layer ended abruptly at the neck of the aneurysm. The aneurysmal wall consisted mainly of connective tissue, and of some poorly stained fragments of elastic lamina. No evidence of polyarteritis nodosa or any other inflammatory reaction was obtained. These findings were the same as those observed in man. Therefore, this aneurysm proved to be of truly spontaneous origin. In contrast to experimental aneurysms in rats and in monkeys, in which aneurysms are observed very often, degenerative changes of the elastic lamina in spontaneous aneurysm in the rat were confined to the neck of the aneurysm. This fact may explain partly the difference in frequency between spontaneous and experimental aneurysms in animals. The present study indicates that degenerative changes of the elastic lamina play a very important role in the development of saccular cerebral aneurysms.
在一只35周龄的Sprague-Dawley大鼠的大脑前动脉开窗分叉处偶然发现一个囊状脑动脉瘤。该动物一直喂食正常的实验室饮食。内膜延伸至动脉瘤颈部一小段距离后突然消失。中层在动脉瘤颈部突然终止。动脉瘤壁主要由结缔组织和一些染色不佳的弹性膜碎片组成。未发现结节性多动脉炎或任何其他炎症反应的证据。这些发现与在人类中观察到的相同。因此，这个动脉瘤被证明是真正自发产生的。与大鼠和猴子中的实验性动脉瘤不同，在大鼠的自发性动脉瘤中，弹性膜的退行性改变仅限于动脉瘤颈部。这一事实可能部分解释了动物自发性和实验性动脉瘤发生频率的差异。本研究表明，弹性膜的退行性改变在囊状脑动脉瘤的形成中起非常重要的作用。
