Hashimoto N, Handa H, Nagata I, Hazama F
Surg Neurol. 1980 Jan;13(1):41-5.
All the rats were made hypertensive and fed beta-aminopropionitrile. Among them, cerebral aneurysms were never found in rats without carotid ligation. In rats with ligation of one or both common carotid arteries, cerebral aneurysms developed on the vessels where hemodynamic stresses were apparently increased. The relationship of hemodynamics in the circle of Willis to the development of cerebral aneurysms is discussed, being compared with findings in spontaneous lesions in man.
所有大鼠均制成高血压模型并喂食β-氨基丙腈。其中，未结扎颈动脉的大鼠未发现脑动脉瘤。在结扎一侧或双侧颈总动脉的大鼠中，脑动脉瘤在血流动力学应力明显增加的血管上形成。本文讨论了 Willis 环中的血流动力学与脑动脉瘤发生的关系，并与人类自发性病变的研究结果进行了比较。
