Arroll Bruce, Dhar Divya, Cullinan Mary
Department of General Practice and Primary Health Care, Faculty of Medicine and Health Science, The University of Auckland, Auckland, New Zealand.
J Prim Health Care. 2010 Mar;2(1):11-5.
Periodontal disease and elevated C-reactive protein (CRP) tests both are positively correlated with cardiovascular disease (CVD) in many studies. Some health practitioners have concerns that root canal treatment may provide a source for inflammation and hence increase the risk for CVD.
To explore the relationship between CRP as a marker of inflammation and presence and number of root canal treatments in primary care patients.
Cross-sectional questionnaire about dental care followed by a blood test for serum CRP in patients from two New Zealand urban family practices.
One hundred and 34 patients participated. The study showed no significant association between CRP and root canal treatment on multivariate analysis controlling for socioeconomic status, age, gender and smoking. The CRP level for those with > or = 3 root-treated teeth was 1.68 while the level for those with < 3 was 2.36, but the p-value was not statistically significant (p = 0.198). Age, missing teeth and smoking were all significantly related to CRP levels so the sample has biological validity.
Root canal treatment was not associated with higher CRP levels. The CRP levels were non-significantly lower in those with higher numbers of root-treated teeth. While there are a number of potential biases in this paper, the dataset appears to be biologically valid and consistent with known facts. These findings do not support the hypothesis that root canal treatment is associated with higher levels of inflammation. At this point patients should not consider having their root canal teeth removed.
在许多研究中，牙周病和C反应蛋白（CRP）检测升高均与心血管疾病（CVD）呈正相关。一些医疗从业者担心根管治疗可能会引发炎症，从而增加患心血管疾病的风险。
探讨在初级保健患者中，作为炎症标志物的CRP与根管治疗的存在及数量之间的关系。
对来自新西兰两个城市家庭诊所的患者进行关于牙科护理的横断面问卷调查，随后进行血清CRP血液检测。
134名患者参与了研究。在对社会经济地位、年龄、性别和吸烟进行多变量分析时，研究表明CRP与根管治疗之间无显著关联。根管治疗牙齿数≥3颗的患者CRP水平为1.68，而<3颗的患者CRP水平为2.36，但p值无统计学意义（p = 0.198）。年龄、缺牙情况和吸烟均与CRP水平显著相关，因此该样本具有生物学有效性。
根管治疗与较高的CRP水平无关。根管治疗牙齿数较多的患者CRP水平虽无显著降低，但也较低。尽管本文存在一些潜在偏差，但数据集似乎具有生物学有效性且与已知事实相符。这些发现不支持根管治疗与更高炎症水平相关的假设。目前，患者不应考虑拔除根管治疗过的牙齿。
