Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
Cancer Invest. 2010 Dec;28(10):1013-8. doi: 10.3109/07357900802620844. Epub 2010 Aug 6.
ABSTRACT Small activating RNAs are a recently discovered group of small, noncoding, and double-stranded RNA molecules that can induce sequence-specific transcriptional gene activation by targeting gene promoter regions. In the present study, we demonstrate that induction of E-cadherin expression by small activating RNA leads to suppression of migration and invasion of PC3 prostate cancer cells. The inhibitory effect was associated with relocalization of β -catenin from the nucleus to the plasma membrane and decreased β -catenin-mediated transactivation. These data suggest that activation of E-cadherin by small activating RNA may have a therapeutic benefit for prostate and other types of cancer.
摘要 小激活 RNA 是一组新发现的小的、非编码的双链 RNA 分子，可通过靶向基因启动子区域诱导序列特异性转录基因激活。在本研究中，我们证明了小激活 RNA 诱导 E-钙黏蛋白表达可抑制 PC3 前列腺癌细胞的迁移和侵袭。抑制作用与 β -连环蛋白从核内重新定位到质膜以及降低 β -连环蛋白介导的转录激活有关。这些数据表明，小激活 RNA 对 E-钙黏蛋白的激活可能对前列腺癌和其他类型的癌症具有治疗益处。
