Papaspiliopoulos Athanasios, Papaparaskeva Kleo, Papadopoulou Eleni, Feroussis John, Papalois Apostolos, Zoubos Aristedes
8th Orthopeadic Department-Shoulder Service, Asklepeion General Hospital, Voula, Athens, Greece.
J Invest Surg. 2010 Aug;23(4):204-7. doi: 10.3109/08941939.2010.481007.
There is still controversy about the effect of anabolic steroid on connective tissue. This study examines the hypothesis that the local use of nandrolone decanoate, an anabolic steroid on rotator cuff, facilitates the healing process when used in combination with surgical repair.
Forty-eight male rabbits were divided in four groups with anabolic steroids (Nandrolone Decanoate 10 mg/kg) and immobilization as variables. The groups were the following: first group, nonsteroid use-immobilization (NSI); second group, nonsteroid use-nonimmobilization (NSNI); third group, steroid use-immobilization (SI); fourth group steroid use-nonimmobilization (SNI). Every rabbit underwent a rotator cuff incision and reconstruction. Fifteen days later the tendons were sent for biomechanical and histological evaluation.
Groups that did not receive anabolic steroids showed better healing and more tendon strength in comparison to groups that received anabolic steroids. Microscopic examination of specimens from the groups without the use of anabolic steroid showed extensive fibroblastic activity whereas the specimens from those groups with anabolic steroid use showed focal fibroblastic reaction and inflammation. Immobilization provided better results in the groups with anabolic steroid use but it did not influence healing in groups without steroids.
The effect of local nandrolone decanoate use on a rotator cuff tear is detrimental, acting as a healing inhibitor.
合成代谢类固醇对结缔组织的影响仍存在争议。本研究检验以下假设：在肩袖上局部使用合成代谢类固醇癸酸诺龙，与手术修复联合使用时可促进愈合过程。
48只雄性兔子按合成代谢类固醇（癸酸诺龙10mg/kg）和固定情况分为四组。分组如下：第一组，不使用类固醇-固定（NSI）；第二组，不使用类固醇-不固定（NSNI）；第三组，使用类固醇-固定（SI）；第四组，使用类固醇-不固定（SNI）。每只兔子均接受肩袖切开和重建手术。15天后，将肌腱送去进行生物力学和组织学评估。
与接受合成代谢类固醇的组相比，未接受合成代谢类固醇的组愈合更好，肌腱强度更高。对未使用合成代谢类固醇组的标本进行显微镜检查，显示有广泛的成纤维细胞活性，而使用合成代谢类固醇组的标本显示有局灶性成纤维细胞反应和炎症。固定在使用合成代谢类固醇的组中效果更好，但对未使用类固醇的组的愈合没有影响。
局部使用癸酸诺龙对肩袖撕裂的影响是有害的，起愈合抑制剂的作用。
