合成代谢雄激素类固醇逆转运动对肌腱生物力学的有益影响：一项实验研究。
Anabolic androgenic steroids reverse the beneficial effect of exercise on tendon biomechanics: an experimental study.
机构信息
Laboratory for Experimental Surgery and Surgical Research "N.S. Christeas", Athens Medical School, Agiou Thoma str. 15B, 11527 Athens, Greece; Charité - University Medicine Berlin, Center for Musculoskeletal Surgery, Augustenburger Platz 1, 13353 Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies, Charité - University Medicine Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
出版信息
Foot Ankle Surg. 2014 Jun;20(2):94-9. doi: 10.1016/j.fas.2013.12.001. Epub 2013 Dec 14.
BACKGROUND
The effect of anabolic androgenic steroids on tendons has not yet been fully elucidated. Aim of the present study was the evaluation of the impact of anabolic androgenic steroids on the biomechanical and histological characteristics of Achilles tendons.
METHODS
Twenty-four male Wistar rats were randomized into four groups with exercise and anabolic steroids (nandrolone decanoate) serving as variables. Protocol duration was 12 weeks. Following euthanasia, tendons' biomechanical properties were tested with the use of a modified clamping configuration. Histological examination with light and electron microscopy were also performed.
RESULTS
In the group of anabolic steroids and exercise the lowest fracture stress values were observed, while in the exercise group the highest ones. Histological examination by light and electron microscopy revealed areas of collagen dysplasia and an increased epitendon in the groups receiving anabolic steroids and exercise.
CONCLUSIONS
These findings suggest that anabolic androgenic steroids reverse the beneficial effect of exercise, thus resulting in inferior maximal stress values.
背景
合成代谢雄激素类固醇对肌腱的影响尚未完全阐明。本研究的目的是评估合成代谢雄激素类固醇对跟腱生物力学和组织学特征的影响。
方法
24 只雄性 Wistar 大鼠随机分为 4 组，以运动和合成代谢类固醇（癸酸诺龙）作为变量。方案持续时间为 12 周。安乐死后，使用改良的夹紧装置测试肌腱的生物力学特性。还进行了光镜和电镜检查。
结果
在接受合成代谢类固醇和运动的组中观察到最低的骨折应力值，而在运动组中观察到最高的骨折应力值。光镜和电镜检查显示，在接受合成代谢类固醇和运动的组中，存在胶原发育不良区和腱旁组织增加。
结论
这些发现表明，合成代谢雄激素类固醇逆转了运动的有益作用，从而导致最大应力值降低。
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