胞壁酰二肽对大鼠已形成的实验性关节炎的影响。

Influence of muramyl dipeptide on established experimental arthritis in rats.

作者信息

Jouzeau J Y, Drelon E, Gillet P, Bannwarth B, Fener P, Charrière G, Payan E, Chauvelot-Moachon L, Batt A M, Floquet J

机构信息

Department of Pharmacology, URA CNRS 1288, Nancy.

出版信息

Agents Actions Suppl. 1991;32:191-5. doi: 10.1007/978-3-0348-7405-2_26.

DOI:10.1007/978-3-0348-7405-2_26

PMID:2069088

Abstract

The effects of MDP, a potent inducer of cytokines, were studied in four batches of Wistar Furth rats with established experimental arthritis. Arthritic rats were given a daily sc injection of 10, 100, 200 or 400 micrograms MDP respectively. Muramyl dipeptide increased the severity of clinical events in a dose-dependent manner, with the exception of the 10 micrograms dose which was ineffective. The levels of anti-collagen antibodies were not however significantly enhanced by MDP. Radiological lesions and histological changes were maximal at high dosage regimens. Paradoxically, the acute phase reactive alpha 1 glycoprotein was little affected by MDP treatment.

摘要

在四组已患实验性关节炎的Wistar Furth大鼠中，研究了细胞因子强效诱导剂MDP的作用。分别给患关节炎的大鼠每日皮下注射10、100、200或400微克MDP。除10微克剂量无效外，胞壁酰二肽以剂量依赖方式增加了临床事件的严重程度。然而，MDP并未显著提高抗胶原蛋白抗体的水平。在高剂量方案下，放射学损伤和组织学变化最为明显。矛盾的是，急性期反应性α1糖蛋白受MDP治疗的影响很小。