胞壁酰二肽在急性炎症实验模型中的抗炎作用。
Anti-inflammatory effects of muramyl dipeptide in experimental models of acute inflammation.
作者信息
Zídek Z, Masek K, Sedivý F
出版信息
Agents Actions. 1984 Jan;14(1):72-5. doi: 10.1007/BF01966836.
Synthetic muramyl dipeptide, N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP), has been tested for activity against acute inflammation. In all models employed (Bayol + Arlacel paw oedema in rats, carrageenan pleurisy in rats, and carrageenan of dextran paw oedema in mice), MDP given in admixture with the phlogistic agents significantly lowered the resulting inflammatory reaction by about 30-40%. 0.1-0.2 mg of MDP per animal was applied. The mechanism of anti-inflammatory activity of this substance remains unknown.
合成的胞壁酰二肽，即N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺（MDP），已被测试其对急性炎症的活性。在所有使用的模型中（大鼠的Bayol + 司班爪水肿、大鼠的角叉菜胶性胸膜炎以及小鼠的右旋糖酐角叉菜胶爪水肿），与致炎剂混合给予的MDP显著降低了由此产生的炎症反应，降低幅度约为30 - 40%。每只动物应用0.1 - 0.2毫克的MDP。该物质抗炎活性的机制仍不清楚。
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