"Petru Poni" Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley No. 41-A, 700487 IASI, Romania.
Mini Rev Med Chem. 2010 Oct;10(11):990-1013. doi: 10.2174/1389557511009010990.
Sol-gel technology is an impressive and instructive innovation in science that necessitates a multidisciplinary approach for its important applications in the practice. An important peculiarity of the sol gel technology is the possibility to control the mechanism and kinetics of the chemical reactions, thus monitoring the final structure (particle size, porosity, thin layer thickness) of the materials. The low processing temperature combined with the intrinsic bio-compatibility and environmental friendliness of the implied components makes it an ideal method applied in different biomedical purposes: the synthesis of porous matrices for entrapping of organic and inorganic compounds, sensor molecules, enzymes and many other biological molecules, selective coatings for optical and electrochemical biosensors, stationary phases for chromatography, immunoadsorbent and solid-phase extraction materials, controlled release agents, solid-phase biosynthesis, and unique matrices for biophysical studies. It is therefore the scope of this review to provide a few insights of the recent progresses made in sol-gel-based materials for biomedical applications.
溶胶-凝胶技术是科学领域一项令人印象深刻且具有启发性的创新,需要采用多学科方法来实现其在实践中的重要应用。溶胶-凝胶技术的一个重要特点是能够控制化学反应的机制和动力学,从而监测材料的最终结构(颗粒大小、孔隙率、薄膜厚度)。低加工温度与所涉及成分固有的生物相容性和环境友好性相结合,使其成为应用于不同生物医学领域的理想方法:合成多孔基质以包埋有机和无机化合物、传感器分子、酶和许多其他生物分子、用于光学和电化学生物传感器的选择性涂层、色谱的固定相、免疫吸附剂和固相萃取材料、控释剂、固相生物合成以及用于生物物理研究的独特基质。因此,本文旨在提供一些关于基于溶胶-凝胶的生物医学应用材料的最新进展的见解。