Department of Dermato-allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, Gentofte, Denmark.
Contact Dermatitis. 2010 Sep;63(3):164-7. doi: 10.1111/j.1600-0536.2010.01774.x.
Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) has been one of the most frequent sensitizers since the 1980s. In 2005, the use of MI alone was approved for the preservation of cosmetic and household products in the EU. Before that, MI was used in industrial products, and the first cases of isolated MI contact allergy were published.
To present the prevalence and causes of MI contact allergy.
Patch test results from 2536 dermatitis patients tested with MI at Gentofte University Hospital between May 2006 and February 2010 were analysed. A retrospective investigation of medical records from MI-allergic patients was performed to reveal the causes of their MI contact allergy.
Of patch-tested patients, 1.5% had MI contact allergy. It was associated with occupational dermatitis, hand eczema and age above 40 years. Exposure to MI in cosmetic products was found in 12 (32%) cases, and exposure to MI in occupational products was found in 11 (30%) cases; 5 of the 11 were painters.
The prevalence of MI contact allergy is already at the same level as that of other sensitizing preservatives, which have been on the market for several years, but no rising trend was identified. MI contact allergy was associated with both occupational and consumer products.
自 20 世纪 80 年代以来，甲基氯异噻唑啉酮/甲基异噻唑啉酮（MCI/MI）一直是最常见的致敏剂之一。2005 年，欧盟批准 MI 单独用于保存化妆品和家用产品。在此之前，MI 用于工业产品，首例 MI 接触过敏的病例被发表。
介绍 MI 接触过敏的流行情况和原因。
对 2006 年 5 月至 2010 年 2 月期间在 Gentofte 大学医院接受 MI 斑贴试验的 2536 例皮炎患者的结果进行了分析。对 MI 过敏患者的病历进行了回顾性调查，以揭示其 MI 接触过敏的原因。
接受斑贴试验的患者中，有 1.5%对 MI 过敏。它与职业性皮炎、手部湿疹和年龄大于 40 岁有关。在 12 例（32%）病例中发现 MI 存在于化妆品中，在 11 例（30%）病例中发现 MI 存在于职业产品中；其中 5 例为油漆工。
MI 接触过敏的流行率已经与其他致敏防腐剂相同，这些防腐剂已经上市多年，但未发现上升趋势。MI 接触过敏与职业和消费产品有关。
