Haft Michael A, Park Helen H, Lee Stephanie S, Sprague Jessica M, Eichenfield Lawrence F
Division of Pediatric and Adolescent Dermatology, Rady Children's Hospital, San Diego, California.
Department of Dermatology, University of California San Diego School of Medicine, San Diego, California.
JAAD Int. 2023 Feb 27;11:165-173. doi: 10.1016/j.jdin.2023.02.008. eCollection 2023 Jun.
Chronic hand eczema (CHE) is persistent inflammatory dermatitis that may significantly affect the quality of life, with psychosocial effects, impact on school, work, and leisure activities, influence on socioeconomic status, and high health care costs. Pediatric-CHE (P-CHE) has a high prevalence yet has not been extensively studied in children and adolescents. There is minimal published data on P-CHE in North America, and no specific management guidelines. Limited prevalence data show broad ranges (0.9%-4.4%) in preschool and school children, with 1 study stating up to 10.0% 1-year prevalence for ages 16 to 19 years. Atopic dermatitis and allergic contact dermatitis appear important in the pathogenesis of this disease process, although there is limited pediatric data assessing disease associations and no standardized methodology for evaluating this disorder. Given the potential life-changing consequences of P-CHE, further research into this disease process is warranted to help generate best therapeutic practices and minimize this disease process' morbidity in adulthood.
慢性手部湿疹（CHE）是一种持续性炎症性皮肤病，可能会显著影响生活质量，产生心理社会影响，对学校、工作和休闲活动造成影响，影响社会经济地位，并带来高昂的医疗费用。儿童慢性手部湿疹（P-CHE）的患病率很高，但在儿童和青少年中尚未得到广泛研究。北美关于P-CHE的已发表数据极少，也没有具体的管理指南。有限的患病率数据显示，学龄前和学龄儿童的患病率范围较广（0.9%-4.4%），有一项研究表明，16至19岁人群的1年患病率高达10.0%。特应性皮炎和过敏性接触性皮炎在该疾病过程的发病机制中似乎很重要，尽管评估疾病关联的儿科数据有限，且没有评估该疾病的标准化方法。鉴于P-CHE可能会改变生活，有必要对这一疾病过程进行进一步研究，以帮助形成最佳治疗方案，并将该疾病过程在成年期的发病率降至最低。
