非甾体抗炎药的类固醇节省效力——用新型药物CGP 28238在大鼠炎症模型中的重新评估
Steroid-saving potency of nonsteroidal antiinflammatory agents--a reevaluation with the new agent CGP 28238 in rat inflammatory models.
作者信息
Hirschelmann R, Pöch G, Rafler I, Rickinger O, Giessler J
机构信息
Sektion Pharmazie, Martin-Luther-Universität Halle-Wittenberg, DDR.
出版信息
Agents Actions Suppl. 1991;32:51-7. doi: 10.1007/978-3-0348-7405-2_6.
The steroid-saving activity of the highly potent new non-steroid antiinflammatory agent CGP 28238 was determined in rat carrageenin paw edema and in primary phase of adjuvant arthritis in comparison with indomethacin. Both nonsteroidal agents showed independent synergistic effects with dexamethasone. Thereby, both compounds reduced the dose of the glucocorticoid necessary for equieffective inhibition of inflammation in the same dose range.
与吲哚美辛相比，在大鼠角叉菜胶性足爪肿胀模型和佐剂性关节炎的急性期，测定了高效新型非甾体抗炎药CGP 28238的节省类固醇活性。两种非甾体药物均与地塞米松显示出独立的协同作用。因此，在相同剂量范围内，两种化合物均降低了等效抑制炎症所需的糖皮质激素剂量。
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