Hirschelmann R, Schade R, Bekemeier H
Agents Actions. 1981 Dec;11(6-7):642-4. doi: 10.1007/BF01978776.
In adjuvant-arthritic rats the carrageenin edema of the non-arthritic hind paw was significantly inhibited 24 hours and 3 days after adjuvant injection, but the edema was not influenced at day 14 when the acute phase reaction was still evident and increased anew. Inhibition of the edema in the primary phase may be rather explained by counter-irritation than by the acute phase reaction. No correlation could be found between inhibition of paw swelling and the levels of acute phase reactants after treatment with dexamethasone, indomethacin, aspirin or soybean trypsin inhibitor. It is mainly the secondary phase of adjuvant arthritis which cannot be inhibited by treatment with several proteins. The present results indicate that the acute phase reaction has a negligible modulating influence on the secondary phase of adjuvant arthritis and that consequently the alteration of the acute phase reaction by anti-inflammatory therapy does not seem to disturb a homeostatic mechanism especially regarding the paw swelling.
在佐剂性关节炎大鼠中，佐剂注射后24小时和3天，非关节炎后爪的角叉菜胶性水肿受到显著抑制，但在第14天，当急性期反应仍明显且再次加重时，水肿未受影响。初级阶段水肿的抑制可能更多地是由反刺激而非急性期反应来解释。在用地塞米松、吲哚美辛、阿司匹林或大豆胰蛋白酶抑制剂治疗后，爪肿胀的抑制与急性期反应物水平之间未发现相关性。主要是佐剂性关节炎的次级阶段不能被几种蛋白质治疗所抑制。目前的结果表明，急性期反应对佐剂性关节炎的次级阶段具有可忽略不计的调节影响，因此抗炎治疗引起的急性期反应改变似乎并未干扰特别是关于爪肿胀的稳态机制。
