Carney J A, Toorkey B C
Section of Surgical Pathology, Mayo Clinic, Rochester, MN 55905.
Am J Surg Pathol. 1991 Aug;15(8):722-31. doi: 10.1097/00000478-199108000-00002.
The features of ductal adenoma of the breast, a solid intraductal tumor, include the following: arrays of long, straight, narrow, roughly parallel tubules composed of distinct epithelial and myoepithelial cells; a modest amount of fibrous tissue that separates the ducts from one another; and a fibrous capsule. We found this neoplasm in four women (ages 27 through 61 years) who had the complex of myxomas, spotty pigmentation, endocrine overactivity, and schwannomas, an autosomal dominant familial syndrome. The lesion was bilateral in two of the women. Each of the patients had mammary myxoid mesenchymal lesions typical of the complex. Two tumors were symptomatic (bloody nipple discharge); the four others were not. Five of the six tumors formed palpable masses that were located close to the areola. The mammograms suggested carcinoma. On microscopic examination, four of the six adenomas were mistaken for carcinoma; none recurred or metastasized. Circumstantial evidence suggests that the ductal adenoma of the breast is a component of the complex of myxomas, spotty pigmentation, endocrine overactivity, and schwannomas.
乳腺导管腺瘤是一种实性导管内肿瘤，其特征如下：由不同的上皮细胞和肌上皮细胞组成的长、直、窄且大致平行的小管排列；将导管彼此分隔的适量纤维组织；以及纤维性包膜。我们在四名患有黏液瘤、散在色素沉着、内分泌功能亢进和神经鞘瘤这一常染色体显性遗传家族综合征的女性（年龄在27至61岁之间）中发现了这种肿瘤。两名女性的病变为双侧性。每位患者均有该综合征典型的乳腺黏液样间充质病变。六个肿瘤中有两个有症状（乳头血性溢液）；另外四个没有症状。六个肿瘤中有五个形成了可触及的肿块，位于乳晕附近。乳房X线照片提示为癌。显微镜检查显示，六个腺瘤中有四个被误诊为癌；无一复发或转移。间接证据表明，乳腺导管腺瘤是黏液瘤、散在色素沉着、内分泌功能亢进和神经鞘瘤综合征的一个组成部分。
