早期清除囊性纤维化患者中的铜绿假单胞菌。
Early eradication of Pseudomonas aeruginosa in patients with cystic fibrosis.
机构信息
Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287-2533, USA.
出版信息
Paediatr Respir Rev. 2010 Sep;11(3):177-84. doi: 10.1016/j.prrv.2010.05.003. Epub 2010 Jun 16.
Abstract
Pseudomonas aeruginosa (Pa) is the predominant organism infecting the airways of patients with cystic fibrosis (CF). This organism has an armamentarium of survival mechanisms that allows it to survive in the CF airway. Since colonization and chronic infection with Pa is associated with poorer lung function and increased morbidity and mortality, therapies that can prevent infection could significantly improve the lives of patients with CF. Numerous studies have examined the effects of treatment on the eradication of Pa as a means to ameliorate disease. This article outlines the pathophysiology and clinical implication of Pa acquisition, and reviews the existing treatment regimens aimed at early eradication of Pa in patients with CF.
摘要
铜绿假单胞菌（Pa）是引起囊性纤维化（CF）患者气道感染的主要病原体。该病原体具有一系列生存机制，使其能够在 CF 气道中存活。由于 Pa 的定植和慢性感染与肺功能下降、发病率和死亡率增加有关，因此能够预防感染的治疗方法可以显著改善 CF 患者的生活。许多研究已经研究了治疗对消除 Pa 的影响，以期改善疾病。本文概述了 Pa 获得的病理生理学和临床意义，并回顾了旨在早期消除 CF 患者 Pa 的现有治疗方案。
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