Lee T W R
Leeds Regional Paediatric Cystic Fibrosis Centre, Childrens' Day Hospital, St James's University Hospital, Leeds, UK.
Chron Respir Dis. 2009;6(2):99-107. doi: 10.1177/1479972309104661.
Chronic infection with the environmental bacterium Pseudomonas aeruginosa is associated with greater morbidity and mortality for people with cystic fibrosis. Strict infection control measures including segregation appear to reduce but not eliminate the risk of initial acquisition of the organism. There is now good evidence from randomized controlled trials that early eradication regimens consisting of anti-pseudomonal antibiotics are effective in clearing P. aeruginosa and delaying the development of chronic infection in the majority of subjects. These regimens are safe and cost-effective. Ensuring that such regimens are widely adopted is therefore of considerable importance to improving outcomes for people with cystic fibrosis. The most effective antibiotic regimen, and the effects of new nebulizer technologies and methods to improve concordance remain to be determined.
环境细菌铜绿假单胞菌的慢性感染与囊性纤维化患者更高的发病率和死亡率相关。包括隔离在内的严格感染控制措施似乎能降低但不能消除初次感染该病菌的风险。目前，随机对照试验提供了充分证据，表明由抗假单胞菌抗生素组成的早期根除方案在清除大多数受试者体内的铜绿假单胞菌并延缓慢性感染发展方面是有效的。这些方案安全且具有成本效益。因此，确保这些方案得到广泛采用对于改善囊性纤维化患者的治疗效果至关重要。最有效的抗生素方案以及新型雾化器技术和提高依从性方法的效果仍有待确定。
