Jackson D C, Tang X L, Murti K G, Webster R G, Tregear G W, Bean W J
Department of Microbiology, University of Melbourne, Parkville, Victoria, Australia.
Arch Virol. 1991;118(3-4):199-207. doi: 10.1007/BF01314030.
Immunogold electron microscopy revealed that site-specific antibodies elicited by a synthetic peptide representing the N-terminal sequence (residues 2-10) of influenza virus M2 protein were capable of binding to the surface of virions. Antibody binding was observed with two human influenza virus strains but not with an avian virus strain which has amino acid substitutions in the appropriate sequence of M2. These results provide direct evidence for the presence of M2 in the influenza virion.
免疫金电子显微镜显示，由代表流感病毒M2蛋白N端序列（第2至10位氨基酸残基）的合成肽引发的位点特异性抗体能够与病毒粒子表面结合。在两种人类流感病毒株中观察到抗体结合，但在M2适当序列中存在氨基酸替代的禽流感病毒株中未观察到。这些结果为流感病毒粒子中存在M2提供了直接证据。
