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[因B型流感病毒导致实验性致死性流感时英加韦林对白化小鼠的抗病毒活性]

[Antiviral activity of Ingavirin in experimental lethal influenza due to influenza virus B in albino mice].

作者信息

Zarubaev V V, Garshinina A V, Kalinina N A, Shtro A A, Nebol'sin V E, Kiselev O I

出版信息

Antibiot Khimioter. 2010;55(3-4):8-11.

PMID:20695201
Abstract

The protective activity of Ingavirin against experimental infection caused by influenza B virus was studied on albino mice vs. Arbidol. Oral use of Ingavirin was shown to decrease the infectious titers of the virus in the animal lung tissue, to normalize the body weight dynamics, to lower the mortality and to increase the average lifespan vs. the placebo-treated animals. The activity of Ingavirin was higher than that of the reference drug. The results allowed to consider Ingavirin as a prospective agent for the treatment of influenza infection in humans.

摘要

在白化病小鼠身上研究了因加维林(Ingavirin)相对于阿比朵尔(Arbidol)对乙型流感病毒引起的实验性感染的保护活性。结果表明,与接受安慰剂治疗的动物相比,口服因加维林可降低动物肺组织中病毒的感染滴度,使体重动态恢复正常,降低死亡率并延长平均寿命。因加维林的活性高于参比药物。这些结果使人们可以将因加维林视为治疗人类流感感染的一种有前景的药物。

相似文献

1
[Antiviral activity of Ingavirin in experimental lethal influenza due to influenza virus B in albino mice].[因B型流感病毒导致实验性致死性流感时英加韦林对白化小鼠的抗病毒活性]
Antibiot Khimioter. 2010;55(3-4):8-11.
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[Protective activity of Ingavirin in experimental lethal influenza due to pandemic influenza virus A (H1N1)v in albino mice].[因甲型H1N1流感大流行病毒株导致的实验性致死性流感中因加韦林的保护作用(对白化病小鼠)]
Antibiot Khimioter. 2010;55(5-6):24-31.
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Antibiot Khimioter. 2008;53(7-8):27-30.
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[Prophylactic and therapeutic efficacies of Ingavirin, a novel Russian chemotherapeutic, with respect to influenza pathogen A (H5N1)].新型俄罗斯化疗药物因加维林对甲型流感病毒(H5N1)的预防和治疗效果
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[In vitro and in vivo effects of ingavirin on the ultrastructure and infectivity of influenza virus].英加韦林对流感病毒超微结构和感染性的体外及体内作用
Vopr Virusol. 2011 Sep-Oct;56(5):21-5.
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[Investigation of prophylactic activity of Ingavirin, a new Russian drug, against grippe A virus (H3N2)].
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[Antiviral activity of Ingavirin on an animal model for experimental disseminated adenovirus infection].英加韦林对实验性播散性腺病毒感染动物模型的抗病毒活性
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引用本文的文献

1
Retracted and republished from: "The current state of research on influenza antiviral drug development: drugs in clinical trial and licensed drugs".撤回并重新发布自:“流感抗病毒药物研发的现状:临床试验药物和已获许可药物”。
mBio. 2024 May 8;15(5):e0017524. doi: 10.1128/mbio.00175-24. Epub 2024 Mar 29.
2
Activity of Ingavirin (6-[2-(1H-Imidazol-4-yl)ethylamino]-5-oxo-hexanoic Acid) Against Human Respiratory Viruses in in Vivo Experiments.英加韦林(6-[2-(1H-咪唑-4-基)乙氨基]-5-氧代己酸)在体内实验中对人类呼吸道病毒的活性。
Pharmaceuticals (Basel). 2011 Nov 25;4(12):1518-1534. doi: 10.3390/ph4121518.