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新型俄罗斯化疗药物因加维林对甲型流感病毒(H5N1)的预防和治疗效果

[Prophylactic and therapeutic efficacies of Ingavirin, a novel Russian chemotherapeutic, with respect to influenza pathogen A (H5N1)].

作者信息

Loginova S Ia, Borisevich S V, Shkliaeva O M, Maksimov V A, Bondarev V P, Nebol'sin V E

出版信息

Antibiot Khimioter. 2010;55(7-8):10-2.

PMID:21140557
Abstract

The experimental study of the Ingavirin efficacy against the influenza virus A (H5N1) on intranasally-infected albino mice vs. Tamiflue and Arbidol showed that when used for the prophylaxis, urgent prophylaxis and therapy it was effective in the protectiom of the animals from death. The efficient dose for the prophylaxis of the influenza infection was 5 mg/kg (protective efficacy of 46.7%) and for the urgent prophylaxis and therapy it was 15 mg/kg (protective efficacy of 40.0 and 35.0% respectively).

摘要

英加韦林对经鼻感染甲型流感病毒(H5N1)的白化小鼠的疗效与达菲和阿比多尔的对比实验研究表明,在用于预防、紧急预防和治疗时,它能有效保护动物免于死亡。预防流感感染的有效剂量为5毫克/千克(保护效力为46.7%),紧急预防和治疗的有效剂量为15毫克/千克(保护效力分别为40.0%和35.0%)。

相似文献

1
[Prophylactic and therapeutic efficacies of Ingavirin, a novel Russian chemotherapeutic, with respect to influenza pathogen A (H5N1)].新型俄罗斯化疗药物因加维林对甲型流感病毒(H5N1)的预防和治疗效果
Antibiot Khimioter. 2010;55(7-8):10-2.
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[Therapeutic efficacy of Ingavirin, a new domestic formulation against influenza A virus (H3N2)].[国产新型制剂英加韦林对甲型流感病毒(H3N2)的治疗效果]
Antibiot Khimioter. 2008;53(7-8):27-30.
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[Antiviral activity of Ingavirin in experimental lethal influenza due to influenza virus B in albino mice].[因B型流感病毒导致实验性致死性流感时英加韦林对白化小鼠的抗病毒活性]
Antibiot Khimioter. 2010;55(3-4):8-11.
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[Study of Ingavirin antiviral activity against Mexican pandemic influenza virus A/H1N1/2009 in vitro and in vivo].[英加韦林对2009年墨西哥甲型H1N1大流行性流感病毒的体外和体内抗病毒活性研究]
Antibiot Khimioter. 2010;55(11-12):17-21.
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[Study of the antiviral activity of Russian anti-influenza agents in cell culture and animal models].[俄罗斯抗流感药物在细胞培养和动物模型中的抗病毒活性研究]
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[In vivo efficacy of Ingavirin against pandemic A (H1N1/09)v influenza virus].英加维林对甲型H1N1/09大流行性流感病毒的体内疗效
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[Protective activity of Ingavirin in experimental lethal influenza due to pandemic influenza virus A (H1N1)v in albino mice].[因甲型H1N1流感大流行病毒株导致的实验性致死性流感中因加韦林的保护作用(对白化病小鼠)]
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Antibiot Khimioter. 2008;53(11-12):19-21.
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