Royal Newcastle Centre Department of Dermatology, Rankin Park, NSW, Australia.
Australas J Dermatol. 2010 Aug;51(3):195-7. doi: 10.1111/j.1440-0960.2010.00642.x.
We report a case of cutaneous leishmaniasis in a 3-year-old West African girl with a 3-month history of multiple disfiguring, infiltrated, ulcerating and variably necrotic granulomatous plaques on the limbs and face that occurred after swimming in a river approximately 6 weeks before arriving in Australia. A diagnosis of cutaneous leishmaniasis, a protozoal zoonosis usually transmitted by the Phlebotomus species of sandfly, was considered. The clinico-pathological features were consistent with Leishmania major infection, known to be the major endemic species causing cutaneous leishmaniasis in the country of origin. Because of the presence of lesions on the face, active treatment was instituted. Continuing resolution of all lesions over 6 weeks was noted to occur with cribiform scarring with the use of oral fluconazole 150 mg daily. Oral fluconazole appears to be emerging as a therapy for uncomplicated cutaneous leishmaniasis, with advantages particularly important in paediatrics.
我们报告了一例发生在一名 3 岁西非女孩身上的皮肤利什曼病。该女孩在抵达澳大利亚前 6 周于河中游泳后，四肢和面部出现了多个毁容性、浸润性、溃疡性和不同程度坏死性的肉芽肿性斑块，病史长达 3 个月。考虑诊断为皮肤利什曼病，这是一种由沙蝇属的蚋传播的原生动物人畜共患病。临床病理特征与利什曼原虫感染一致，已知该感染是导致原籍国皮肤利什曼病的主要流行物种。由于面部有病变，进行了积极治疗。在使用每日 150 毫克口服氟康唑治疗的情况下，6 周内所有病变持续消退，形成筛状瘢痕。口服氟康唑似乎正在成为一种治疗非复杂性皮肤利什曼病的方法，在儿科中具有特别重要的优势。
