Receptors and Signal Transduction Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
FEBS Lett. 2010 Dec 15;584(24):4933-40. doi: 10.1016/j.febslet.2010.08.006. Epub 2010 Aug 7.
The aggregation by antigen of the IgE bound to its high affinity receptor on mast cells initiates a complex series of biochemical events that result in the release of inflammatory mediators. The essential role of the protein tyrosine kinase Syk has been appreciated for some time, and newer results have defined the mechanism of its activation. The use of siRNA has defined the relative contribution of Syk, Fyn and Gab2 to signaling and has made possible a screening study to identify previously unrecognized molecules that are involved in these pathways.
抗原与肥大细胞表面高亲和力受体结合的 IgE 聚集，引发了一系列复杂的生化事件，导致炎症介质的释放。蛋白酪氨酸激酶 Syk 的重要作用已经被人们认识了一段时间，而新的研究结果定义了其激活的机制。siRNA 的使用定义了 Syk、Fyn 和 Gab2 在信号转导中的相对贡献，并使得进行筛选研究以鉴定以前未被识别的参与这些途径的分子成为可能。
