Caglayan Ahmet Okay
Kayseri Education and Research Hospital, Department of Medical Genetics, 38010 Kayseri, Turkey.
Interact Cardiovasc Thorac Surg. 2010 Dec;11(6):779-83. doi: 10.1510/icvts.2010.245910. Epub 2010 Aug 9.
Atrial fibrillation (AF) is a consequence of a complex interplay of genetic, epigenetic and environmental factors. In addition, AF is a major contributor to stroke, heart failure, and mortality. Several family studies have shown a strong polygenetic predisposition for AF but, so far, most of the linkage analysis and candidate gene studies have discovered only monogenic, rare, deleterious mutations. While research in human genetics has moved from monogenic to oligogenic to complex diseases, its pharmacogenetics branch has followed, usually a few years behind. The present paper reviews the potential contributions of genetic approaches to AF.
心房颤动（AF）是遗传、表观遗传和环境因素复杂相互作用的结果。此外，AF是导致中风、心力衰竭和死亡的主要因素。多项家族研究表明AF具有很强的多基因易感性，但迄今为止，大多数连锁分析和候选基因研究仅发现了单基因、罕见、有害的突变。虽然人类遗传学研究已从单基因疾病转向寡基因疾病再到复杂疾病，但其药物遗传学分支通常会滞后几年。本文综述了基因方法对AF的潜在贡献。
